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Rice Endosperm Specific Expressed Human Serum Protein Without Any Contaminants Risk

Categories Recombinant Serum Albumin
Brand Name: Oryzogen
Model Number: HY100M1
Certification: ISO 9001 certificate
Place of Origin: China
MOQ: Negotiation
Price: Negotiation
Payment Terms: T/T
Supply Ability: 1000kg per year
Delivery Time: 3-5 days
Packaging Details: 1g/vial 10g/vial 50g/vial
Source: Rice Grain(Oryza Sativa)
Molecular Weight: 66.5kD
Endotoxin: Less than 0.25EU/mg
Usage: Cell Culture, stem cell culture, vaccine reseach
Production Type: Recombinant protein
EINECS No.: 274-272-6
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    Rice Endosperm Specific Expressed Human Serum Protein Without Any Contaminants Risk

    Rice Endosperm Specific Expressed Human Serum Protein Without Any Contaminants Risk​


    Quick detail

    1. CAS No.: 70024-90-7
    2. Other Names: rHSA
    3. EINECS No.: 274-272-6
    4. Place of Origin: Hubei, China (Mainland)
    5. Brand Name: Oryzogen
    6. Source: Rice Grain (Oryza Sativa)
    7. Endotoxin: Less than 0.25EU/mg
    8. Storage and Handling: Stored at temperatures 2-8℃ for 24 months

    Physiological and Biochemical Properties of rHSA and pHSA

    Char.pHSArHSA
    Amino Acids SequenceSameSame
    N-terminusDAHKSEVDAHKSEV
    C-terminusKLVAASQAALGLKLVAASQAALGL
    GlycosylationNoNo
    Molecular Mass(MALDI)66.554KD66.550KD
    PI4.84.8
    Drug BindingSimilarSimilar
    Thermal StabilityM/P 65℃M/P 65℃
    Lipid ConjugationIdenticalIdentical
    Crystal StructureIdenticalIdentical

    Description

    Healthgen uses State-of-the-art platform called OryzHiExp, having high capacity to express proteins and peptides in the rice grain. The platform uses rice endosperm cells as a bioreactor to specifically and highly express various recombinant proteins and small peptides. The platform is a rice-specific endosperm cell-specific expression platform that focuses on the expression of animal-free products, safe recombinant proteins and peptides. We use this technique to express recombinant human serum albumin to achieve higher safety and biosafety.


    Advantages

    1. The chairman of Healthgen Professor Daichang.Yang is one of China's chief scientists. Professor Yang has rechieved the “Thousand Talents program” of the National Central Organization Department, "Hundred Talents Program" of the Organization Department of Hubei Province and Top 10 "Venture Eagle" entrepreneurs.


    2. With years of effort, Healthgen has developed the State-of-the-Art platform called OryzHiExp, having high capacity to express no animal origin proteins and peptides in the rice endosperm cells.


    3. Healthgen recombinant human serum albumin is free of animal origin, which effectively avoid any potential risk of animal bacteria, prions, virus and contagious protein disease.


    Supplemental Description

    The research results have been granted with 16 international patents, covering countries, such as United States, Japan, Europe, Canada and South Africa. Parts of the patents are showed as below:


    A callus-specific promoter of rice and the use thereof

    China patent no. 201110054109.X

    Method for expressing small peptides using cereal non-storage proteins as fusion carrier in endosperm and the use thereof

    US patent no. US20070289033

    Japan patent no. JP2007-325594A

    Europe patent no. EP1865064

    Canada patent no. CA2587092

    China patent no. 200610019285.9

    A method for extracting recombinant human serum albumin from transgenic rice grain

    South Africa patent no. 2013/04359

    China patent no. 201010597544.2

    A method for isolating and purifying recombinant human serum albumin from transgenic rice grain;

    South Africa patent no. 2013/04358

    China patent no. 201010606635.8

    A method for isolating and purifying recombinant human serum albumin from transgenic rice grain

    South Africa patent no. 2013/04358

    US patent no. US9023990 B2

    Production of recombinant human serum albumin with rice endosperm cells as biological reactor

    China patent no. ZL 2005 1 0019084.4


    Based on the innovative technology, Healthgen also published research papers.


    Publications

    1. He Y, et al. Large-scale production of functional human serum albumin from transgenic rice seeds. Proc Natl Acad Sci USA. 2011;108:19078-19083.

    2. Na An, et al. Expression of a Functional Recombinant Human Basic fibroblast Growth Factor from Transgenic Rice Seeds. Int. J. Mol. Sci. 2013, 14, 3556-3567

    3. Liping Z, et al. Expression and characterization of recombinant human alpha-antitrypsin in transgenic rice seed. Journal of Biotechnology. 2012; 164: 300-308.

    4. Xie, T, et al. A biologically active rhIGF-1 fusion accumulated in transgenic rice seeds can reduce blood glucose in diabetic mice via oral delivery. Peptides 2008: 29: 1862-1870.

    5. Zhen Chen, et al. Human serum albumin from recombinant DNA technology: challenges and strategies. Biochimica et Biophysica Acta. 2013; 1830: 5515-5525.

    6. Zhen Chen, et al. Quantitation of the residual DNA from rice-derived recombinant human serum albumin. Analytical Biochemistry. 2014; 450: 4-10.

    7. Jiquan Ou, et al. Transgenic rice endosperm as a bioreactor for molecular pharming. Plant Cell Rep (2014) 33:585–594

    8. Kai fu, et al. Immunotoxicity assessment of rice-derived recombinant human serum albumin using human peripheral blood mononuclear cells. PLoS ONE 01/2014; 9(8): e104426.


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