USP Fungicidal Chlorhexidine Digluconate For Anti-Fungicidal :
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Chlorhexidine digluconate Description:
Chlorhexidine digluconate is commercially available as a 20% (w/v)
aqueous solution since the substance cannot be isolated as a solid.
It is soluble in water to at least 50% (w/v) but high viscosity
makes such concentrated solutions inconvenient to use. Autoclaving
of solutions greater than 1.0% can result in the formation of
insoluble residues and is therefore unsuitable. If sterile
solutions are required at such high concentrations, then filtration
through a 0.22 m membrane filter is recommended. Dilute
chlorhexidine solutions may be stored at room temperature, and a
shelf-life of at least 1 year can be expected, provided that the
packaging is adequate. Prolonged exposure to high temperature or
light is to be avoided because this can adversely
Affect the stability of chlorhexidine solutions. All dilute
solutions to be stored should be either heat-treated (sterilized or
pasteurized) or chemically preserved (4% isopropanol or 7% ethanol)
to eliminate the possibility of microbial contamination. For
autoclaved solutions the choice of container material is important,
best results being achieved with neutral glass or polypropylene. If
soda glass is used with chlorhexidine solutions the resultant pH
may be above that which is considered optimal for stability (pH
5-7)because of leaching of alkaline materials from the bottle".
Product Name: Chlorhexidine digluconate
Appearance: Clear liquid, colorless to very faint yellow in color,
offered as approximately 20% (w/v)
Molecular Formula: C34H54Cl2N10O14
Molecular Weight: 897.76
Major Usage: anti-microbial with proven effects against both
gram-positive and gram negative organisms. Fungicidal and
Advantages: While Chlorhexidine's primary benefit is its tremendous
ability to kill bacteria on contact, it has a residual effect that
prevents microbial regrowth after application, giving it a marked
advantage over products such as Triclosan, PCMX or alcohols.
Take nitazoxanide exactly as directed by your doctor. If you do not
understand these instructions, ask your pharmacist, nurse, or
doctor to explain them to you. Take nitazoxanide with food.
Shake the suspension well before measuring a dose. To ensure that
you get the correct dose, measure the suspension with a
dose-measuring spoon, dropper, or cup, not with a regular table
spoon. If you do not have a dose-measuring device, ask your
pharmacist where you can get one.
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