Vitamin nutrition bone metabolism index calibrator test kit for
Clinical In Vitro Diagnostic analyzer
Bone metabolism markers can check calcium and phosphorus metabolism
indicators, bone formation markers, bone resorption markers, etc.,
are the detection of metabolites produced by bone transformation,
and can reflect the body's skeletal conditions, such as the rate of
change in bone metabolism, osteoclasts and osteoblasts. Function,
frequency and rate of bone turnover, etc., are helpful for the
diagnosis of osteoporosis, osteomalacia and other diseases.
1. Calcium and phosphorus metabolism indicators: including parathyroid hormone, calcitonin, etc., by evaluating
the body's calcium and phosphorus metabolism ratio, observing
osteogenesis, and reducing the risk of rickets, rickets and other
diseases;
2. Bone formation markers: including alkaline phosphatase, serum osteocalcin, type I
procollagen propeptide, etc. Among them, alkaline phosphatase can
evaluate osteoblast activity and bone formation, and serum
osteocalcin can reflect bone formation It can also detect the
efficacy of drugs used in osteoporosis, etc. And type I procollagen
propeptide has more direct diagnostic significance for metabolic
bone disease affecting collagen formation;
3. Bone resorption markers: including urinary calcium, urinary hydroxyproline, hydroxylysine
glycosides, etc. Urinary calcium level detection can reflect the
bone resorption status, but it is easily affected by diet,
intestinal absorption function, etc., so it lacks specificity .
Urinary hydroxyproline, hydroxylysine glycosides, etc. can reflect
the state of collagen conversion in the whole body. In addition,
indicators such as urinary deoxypyridinoline and urinary type I
collagen carboxy-terminal peptide can also be checked.
CLIA calibrator of Bone Metabolism
| ITEM | 25-OH-Vit-D |
| BGP |
| iPTH |
| CT |
| CTX |
| PINP |
| Testing method | 1. Treat the calibrator as the sample to be tested, and place it in
the sample loading area of the instrument after mixing. Note that
when mixing
Avoid air bubbles.
2. During the detection, the system detects the luminescence value
(RLU value) of each calibration point, and calculates the
luminescence value according to the nominal concentration and
luminescence value.
The calibration curve is automatically fitted by the instrument. In
order to ensure the reliability of the calibration curve, the
determination of the calibrator should be
Make a double.
3. The generated calibration curve can be used for 28 days, but it
should be re-calibrated after the following conditions:
Change of batch number of supporting testing reagents;
Change of batch number of luminescent substrate
The measured value of the quality control product is not within
the scope of quality control or the test results are inconsistent
with the clinical situation;
System for major repairs or maintenance. |
| Interpretation of test results | 1. For reasons such as methodology or antibody specificity, the
same sample was tested using reagents from different manufacturers.
Testing with different reagents may give different test results,
therefore, the results obtained by testing with different reagents
should not be directly
They are compared with each other in order to avoid false medical
interpretations.
2. The quality control product can be used as a reference for the
reliability of the current experimental results, and its measured
value should be within the
within the range allowed by the quality control sheet. Test results
should be based on reference value ranges and other clinical
factors and results
Comprehensive judgment, when the test result is close to the upper
limit or lower limit of the reference value range, it can be
considered
samples for confirmation testing. |
| Storage and expiration date | Stored at 2-8°C, the product is valid for 12 months. Reagents
should be used within 1 month after opening, and stored at 2-8°C
away from direct sunlight.
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