Diagnostic reagent kit Collagenase IV(CIV) for Automatic immunoassay analyzer in Hepatic Fibrosis

Diagnostic reagent kit Collagenase IV(CIV) for Automatic immunoassay analyzer in Hepatic Fibrosis

It is used to quantitatively detect the content of type IV collagen (CIV) in human serum in vitro.
In normal liver, type IV collagen is mainly distributed in the basement membrane of blood vessels and bile ducts, and there is no obvious deposition in liver sinusoids.

When hepatic fibrosis occurs, type IV collagen may be the earliest proliferating fibrils, with a high turnover rate, a large amount of deposition, and finally forming a complete basement membrane with the continuous deposition of laminin. At present, it is believed that type IV collagen is an indicator that reflects the production of collagen rather than its degradation, and is related to the degree of liver fibrosis. Type IV collagen and serum hyaluronic acid (HA), laminin (LN) and type III procollagen N-terminal peptide can be used as one of the indicators reflecting the degree of liver fibrosis.

The levels of these indicators are related to the development stage of chronic hepatitis. Consistently, it was at the highest level in the stages of chronic severe hepatitis and cirrhosis, and was also consistent with the degree of inflammation, necrosis and fibrosis of liver tissue, and the highest level was in inflammation grade G4 and fibrosis stage S4. Therefore, the level of serum type IV collagen, together with other indicators such as serum hyaluronic acid (HA), laminin (LN), and type III procollagen N-terminal peptide (PIIINP), becomes an important tool for judging the severity of liver disease, identifying the presence or absence of liver cirrhosis, and predicting the severity of liver disease. Good serological indicator of trends.

Zecen Biotech CO., LTD., founded in 2011, is a leading Chinese diagnostics manufacturer specializing in in-vitro diagnostics devices and reagents. Zecen focus on the Chemiluminescent immunoassay (CLIA) field. With all products CE marked, our market presence currently spreads from across China to other countries including India, Switzerland, Russia etc., Zecen is expanding its footprint to become a global brand.

Zecen is the only enterprise with independent intellectual property rights in the entire chemiluminescence industry chain in China, including reagent, instrument, magnetic microbead, and reagent raw material. Our current products include more than 100 assays, from thyroid, inflammation, diabetes, tumer markers, immune disorders, hormones to cardiac markers. Our ever-expanding test menu helps our customers and collaborators keep up with the demands of healthcare sector. Zecen is striving for innovation and perfection to deliver the best products to the customers.

As a manufacturer, Zecen provide the OEM, ODM and other customized service of all products. We have the core R&D centers and innovative ability to lay a solid foundation for developing the broadest range of CLIA analyzers and test menu. High-quality sales and after-sales links provide the more intimate service. The patent and CE certification give us the confident sending all over the world, and more than 50 companys in the requiement of customized and have a long term coorperation with Zecen.